The Argentinian has picked up a thigh injury while the captain's soleus problem has been confirmed and neither will feature in Wednesday's Copa del Rey quarter final
Wednesday night at 9.00pm CET, Espanyol host FC Barcelona in a Copa del Rey quarter final first leg for which Ernesto Valverde is going to have to make do without Andrés Iniesta, with a soleus injury in his right leg, and Javier Mascherano, with left thigh trouble.
That’s in addition to the already injured Samuel Umtiti, Paco Alcácer, Philippe Coutinho and Ousmane Dembélé.
But on the plus side, the Barça boss regains the services of Nélson Semedo, who has been out for a few days with tonsillitis.
The Portuguese defender is back in the squad, which reads as follows: Ter Stegen, Cillessen, Semedo, Piqué, Rakitic, Sergio Busquets, Denis Suárez, Luis Suárez, Messi, Rafinha, Paulinho, Jordi Alba, Digne, Sergi Roberto, André Gomes, Aleix Vidal, Vermaelen and, from Barça B, Carles Aleñá (26).
New signing Yerry Mina, who still has paperwork to sort out before he is clear to play, and Gerard Deulofeu also miss out.
Goalkeeper Alberto Varo of the reserves also joined the first team for Tuesday’s training session on the Tito Vilanova field, the last before the latest edition of the oldest fixture in Spanish football.