Last season Anderlecht reached the Final Four in Nyon and lost 3-1 in the semi-finals to Shakhtar Donetsk.
Juanma, Ferran, Vilanova, Theo, Andreu and Carbonell were all in the team that lost 1-0 in Belgium last season, and will be out to get revenge when the sides meet again.
Jorn Vancamp is their top scorer with five goals from five games. Leya Iseka, who scored the solitary goal against Barça last year has only played in one game this time round.
The team is managed by 34-year-old Argentinian Nicolás Frutos, who played for many years in the Belgian league but also spent time in Spain at UD Las Palmas.
Last season’s meeting between Anderlecht and Barça set a UEFA Youth League record for its attendance of 12,871 at the Constant Vaden Stock stadium, where the first team usually plays.
The RSC in their name comes from Royal Sporting Club Anderlecht.
To reach the quarter finals, Anderlecht eliminated SK Brann (Norway), Servette (Switzerland), Arsenal (England) and GNK Dinamo (Croatia), although they actually lost 2-0 to the latter, who were subsequently disqualified for fielding an ineligible player.
The first team has more Belgian league titles than any other club (33). Next in line are Club Brugge (13).
The game will be played at the Van Roy Stadium, which holds 5,166 spectators. It’s located in Denderleeuw, on the outskirts of Brussels.
Anderlecht’s first team has made it into the last sixteen of the Europa League, where they have been drawn to play Shakhtar Donetsk in March.